Kevin Rose on metabolism and first tier bio-markers

2024-05-18 12:37:00 +07:00 by Mark Smith

Kevin Rose's latest podcast, a discussion with Dr Casey Means, has all sorts of valuable information about how human bodies transform food into cellular energy. It's an important fundamental process of the body that I think is important to understand. I've extracted some of the most important details in this post. It's likely I didn't totally grock everything, but I think nevertheless it's important information to at least be aware of, to have a general idea of what's happening at the cellular level.

First tier Bio markers important for metabolism, lifestyle based:

Generally speaking you want to stay within these ranges.

Some more detailed information about each of these:

Fasting glucose


Haemoglobin A1C

Waist circumference

Blood pressure

They go into a rather detailed discussion about second tier bio-markers, which was kind of interesting in places, but a bit too hardcore for me. All the language and primitives around health and body, like proteins, hormones, etc is still very non obvious to me. I got pretty lost in the second tier weeds. But I still think it's worth having a general understanding, especially of the fundamental first tier stuff.

One of the biggest take aways from second tier is that you have to understand what the markers are telling you. It's much like debugging complex code. If you don't have the right understanding of the fundanental processes, you might very well be fooling yourself. For example fasting insulin is an important second tier bio-marker because it indicates that there might be a problem with the fundamental operation of the mitochondria, since the body produces insolin in order to force the glucose into the cell. This might work for a while but eventually leads to issues.

So you can see these issues ahead of time if you are tracking the right bio-markers.

As a javascript programming analogy, it's like understanding the NodeJS event loop in detail. You don't often have to worry about it, but in certain circumstances it is vital.

These are slighlty edited version of the notes I took while listening. I feel like there's still quite a lot of refactoring that could be done here on this to make it clearer, but I really like the approach.

Hopefully this post will add to the process of a more wide spread understanding how our bodies function.

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